Select Incumbent Paradigm to Analyze
Breaking (4-5 forces stressed)
Stressed (2-3 forces)
Stable (0-1 forces)
Select Emerging Paradigm to Analyze
Foundation (core position)
Active (direct alpha)
Frontier (tracking only)
Case Studies

Historical Medical Paradigm Shifts

Analyzing past healthcare transitions to understand the patterns that predict paradigm shifts in human health

Framework Validation

Historical Health Backtests

Apply the M31 5 Forces + 5 Signals framework to historical healthcare paradigm shifts

Featured Backtests
Validated
Cannabis 2012
Fortress Siege archetype. State-by-state domino.
INVEST 2012
Validated
GLP-1 2017
Quiet Revolution. Metabolic disease inverted.
INVEST 2017
Failure Case
Theranos 2014
The Capture. No scientific unlock.
AVOID 2014